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Literature summary extracted from

  • Zavodszky, P.; Gal, P.; Cseh, S.; Schumaker, V.N.
    Protein engineering studies on C1r and C1s (1993), Behring Inst. Mitt., 93, 103-114.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.42 the full length cDNA of C1s is placed under the control of the strong polyhedrin promoter of Autographa californica nuclear polyhedrosis virus, expression in Sf9, High5 cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.41 additional information by the point mutation of C1r - Arg-Phe - of the natural cleavage site Arg-Ile - the zymogen is stabilized, while the biological activity is not affected Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.41 Homo sapiens
-
-
-
3.4.21.42 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.41 side-chain modification postranslational modification of C1r by beta-hydroxylation of specific Asp and Asn residues, 10% of the recombinant C1r is hydroxylated Homo sapiens
3.4.21.42 no modification no beta-hydroxy-Asn is found in the recombinant enzyme Homo sapiens
3.4.21.42 side-chain modification in the recombinant protein the incompletely processed N-linked carbohydrate chain lacks at least the terminal sialic acid residue Homo sapiens