EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.21.42 | the full length cDNA of C1s is placed under the control of the strong polyhedrin promoter of Autographa californica nuclear polyhedrosis virus, expression in Sf9, High5 cells | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.4.21.41 | additional information | by the point mutation of C1r - Arg-Phe - of the natural cleavage site Arg-Ile - the zymogen is stabilized, while the biological activity is not affected | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.41 | Homo sapiens | - |
- |
- |
3.4.21.42 | Homo sapiens | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
3.4.21.41 | side-chain modification | postranslational modification of C1r by beta-hydroxylation of specific Asp and Asn residues, 10% of the recombinant C1r is hydroxylated | Homo sapiens |
3.4.21.42 | no modification | no beta-hydroxy-Asn is found in the recombinant enzyme | Homo sapiens |
3.4.21.42 | side-chain modification | in the recombinant protein the incompletely processed N-linked carbohydrate chain lacks at least the terminal sialic acid residue | Homo sapiens |